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Affective Instability, Childhood Trauma and Major Affective Disorders

Marwaha, S. and Gordon-Smith, Katherine and Broome, M. and Briley, P. and Forty, L. and Perry, Amy and Craddock, N. and Jones, I. and Jones, Lisa (2016) Affective Instability, Childhood Trauma and Major Affective Disorders. In: 18th Annual Conference of the International Society for Bipolar Disorders & 8th Biennial Conference of the International Society for Affective Disorders, 13th - 16th July 2016, Amsterdam, The Netherlands. (Unpublished)

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Abstract

Background and Aims Affective instability (AI), childhood trauma, and mental illness are linked, but evidence in affective disorders is limited, despite both AI and childhood trauma being associated with poorer outcomes. Aims were to compare AI levels in bipolar disorder I (BPI) and II (BPII), and major depressive disorder recurrent (MDDR), and to examine the association of AI and childhood trauma within each diagnostic group. Methods AI, measured using the Affective Lability Scale (ALS), was compared between people with DSM-IV BPI (n = 923), BPII (n = 363) and MDDR (n = 207) accounting for confounders and current mood. Regression modelling was used to examine the association between AI and childhood traumas in each diagnostic group. Results ALS scores in descending order were BPII, BPI, MDDR, and differences between groups were significant (p < 0.05). Within the BPI group any childhood abuse (p = 0.021), childhood physical abuse (p = 0.003) and the death of a close friend in childhood (p = 0.002) were significantly associated with higher ALS score but no association was found between childhood trauma and AI in BPII and MDDR. Conclusions AI is an important dimension in bipolar disorder independent of current mood state. There is a strong link between childhood traumatic events and AI levels in BPI and this may be one way in which exposure and disorder are linked. Clinical interventions targeting AI in people who have suffered significant childhood trauma could potentially change the clinical course of bipolar disorder.

Item Type: Conference or Workshop Item (Other)
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The full-text cannot be supplied for this item.
The published abstract for this talk is available in the journal 'Bipolar Disorder', Volume 18, Issue SI, RC-04 on p. 62.

Uncontrolled Keywords: affective instability, childhood trauma, major affective disorders
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Katherine Gordon-Smith
Date Deposited: 26 Sep 2016 10:54
Last Modified: 26 Sep 2016 10:54
URI: https://eprints.worc.ac.uk/id/eprint/4921

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