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Hydrogenated Fat Intake during Pregnancy and Lactation Modifies Serum Lipid Profile and Adipokine mRNA in 21-day-old Rats

Pisani, L.P. and Oyama, L.M. and Bueno, Allain and Biz, C. and Albuquerque, K.T. and Ribeiro, E.B. and Oller do Nascimento, C.M. (2008) Hydrogenated Fat Intake during Pregnancy and Lactation Modifies Serum Lipid Profile and Adipokine mRNA in 21-day-old Rats. Nutrition, 24 (3). pp. 255-261. ISSN 0899-9007

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Abstract

Objective We examined whether feeding pregnant and lactating rats hydrogenated fats rich in trans-fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 21-d-old offspring. Methods Pregnant and lactating Wistar rats were fed with a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). After delivery, male offspring were weighed weekly and killed at day 21 of life by decapitation. Blood and retroperitoneal, epididymal, and subcutaneous white adipose tissues were collected. Results Offspring of T-group rats had increased serum triacylglycerols and cholesterol, white adipose tissue plasminogen activator inhibitor-1, and tumor necrosis factor-α gene expression, and carcass lipid content and decreased blood leptin and adiponectin and adiponectin gene expression. Conclusion Ingestion of hydrogenated vegetable fat by the mother during gestation and lactation alters the blood lipid profiles and the expression of proinflammatory adipokynes by the adipose tissue of offspring aged 21 d.

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Uncontrolled Keywords: hydrogenated fat;, adiponectin, Plasminogen activator inhibitor-1, tumor necrosis factor-α, gestation, lactation, dyslipidemia, clinical nutrition
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Tanya Buchanan
Date Deposited: 09 Aug 2016 13:23
Last Modified: 09 Aug 2016 13:23
URI: https://eprints.worc.ac.uk/id/eprint/4765

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