University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Gut Microbiota, Probiotics and Diabetes

Gomes, A.C. and Bueno, Allain and Machado de Souza, R.G. and Mota, J.F. (2014) Gut Microbiota, Probiotics and Diabetes. Nutrition Journal, 13 (60). pp. 1-13. ISSN Print: 1475-2891 Online: 1475-2891

[img]
Preview
Text
Gut microbiota probiotics and diabetes.pdf - Published Version
Available under License Creative Commons Attribution.

Download (721kB) | Preview

Abstract

Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes.

Item Type: Article
Additional Information:

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Uncontrolled Keywords: probiotics, diabetes mellitus, gut microbiota, inflammation, insulin resistance, human nutrition
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: Academic Departments > Institute of Science and the Environment
Related URLs:
Copyright Info: Open Access journal
Depositing User: Tanya Buchanan
Date Deposited: 09 Aug 2016 12:58
Last Modified: 09 Aug 2016 13:12
URI: https://eprints.worc.ac.uk/id/eprint/4763

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.