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Effects of Different Fatty Acids and Dietary Lipids on Adiponectin Gene Expression in 3T3-L1 Cells and C57BL/6J Mice Adipose Tissue

Bueno, Allain and Oyama, L.M. and de Oliveira, C. and Pisani, L.P. and Ribeiro, E.B. and Silveira, V.L.F. and Oller do Nascimento, C.M. (2008) Effects of Different Fatty Acids and Dietary Lipids on Adiponectin Gene Expression in 3T3-L1 Cells and C57BL/6J Mice Adipose Tissue. Pflügers Archiv - European Journal of Physiology, 455 (4). pp. 701-709. ISSN Print: 0031-6768 Online: 1432-2013

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Abstract

Obesity is positively correlated to dietary lipid intake, and the type of lipid may play a causal role in the development of obesity-related pathologies. A major protein secreted by adipose tissue is adiponectin, which has antiatherogenic and antidiabetic properties. The aim of this study was to evaluate the effects of four different high-fat diets (enriched with soybean oil, fish oil, coconut oil, or lard) on adiponectin gene expression and secretion by the white adipose tissue (WAT) of mice fed on a selected diet for either 2 (acute treatment) or 60 days (chronic treatment). Additionally, 3T3-L1 adipocytes were treated for 48 h with six different fatty acids: palmitic, linoleic, eicosapentaenoic (EPA), docosahexaenoic (DHA), lauric, or oleic acid. Serum adiponectin concentration was reduced in the soybean-, coconut-, and lard-enriched diets in both groups. Adiponectin gene expression was lower in retroperitoneal WAT after acute treatment with all diets. The same reduction in levels of adiponectin gene expression was observed in epididymal adipose tissue of animals chronically fed soybean and coconut diets and in 3T3-L1 cells treated with palmitic, linoleic, EPA, and DHA acids. These results indicate that the intake of certain fatty acids may affect serum adiponectin levels in mice and adiponectin gene expression in mouse WAT and 3T3-L1 adipocytes. The effects appear to be time dependent and depot specific. It is postulated that the downregulation of adiponectin expression by dietary enrichment with soybean oil or coconut oil may contribute to the development of insulin resistance and atherosclerosis.

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Uncontrolled Keywords: white adipose tissues, Adiponectin, high-fat diets, mice, 3T3-L1, obesity, dietary lipids
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Tanya Buchanan
Date Deposited: 09 Aug 2016 12:07
Last Modified: 09 Aug 2016 12:07
URI: https://eprints.worc.ac.uk/id/eprint/4757

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