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Deleterious Effects of Lard-enriched Diet on Tissues Fatty Acids Composition and Hypothalamic Insulin Actions

Dornellas, A.P.S. and Watanabe, R.L.H. and Pimentel, G.D. and Boldarine, V.T. and Nascimento, C.M.O. and Oyama, L.M. and Ghebremeskel, K. and Wang, Y. and Bueno, Allain and Ribeiro, E.B. (2015) Deleterious Effects of Lard-enriched Diet on Tissues Fatty Acids Composition and Hypothalamic Insulin Actions. Prostaglandins, Leukotrienes and Essential Fatty Acids, 102-3. pp. 21-29. ISSN 0952-3278

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Abstract

Altered tissue fatty acid (FA) composition may affect mechanisms involved in the control of energy homeostasis, including central insulin actions. In rats fed either standard chow or a lard-enriched chow (high in saturated/low in polyunsaturated FA, HS-LP) for eight weeks, we examined the FA composition of blood, hypothalamus, liver, and retroperitoneal, epididymal and mesenteric adipose tissues. Insulin-induced hypophagia and hypothalamic signaling were evaluated after intracerebroventricular insulin injection. HS-LP feeding increased saturated FA content in adipose tissues and serum while it decreased polyunsaturated FA content of adipose tissues, serum, and liver. Hypothalamic C20:5n-3 and C20:3n-6 contents increased while monounsaturated FA content decreased. HS-LP rats showed hyperglycemia, impaired insulin-induced hypophagia and hypothalamic insulin signaling. The results showed that, upon HS-LP feeding, peripheral tissues underwent potentially deleterious alterations in their FA composition, whist the hypothalamus was relatively preserved. However, hypothalamic insulin signaling and hypophagia were drastically impaired. These findings suggest that impairment of hypothalamic insulin actions by HS-LP feeding was not related to tissue FA composition.

Item Type: Article
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Uncontrolled Keywords: fatty acid, obesity, diet, insulin signaling, Adipose tissue, Hypothalamus, dietary fats, lipids, biochemistry
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Tanya Buchanan
Date Deposited: 09 Aug 2016 11:13
Last Modified: 09 Aug 2016 11:13
URI: https://eprints.worc.ac.uk/id/eprint/4755

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