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A Palatable Hyperlipidic Diet Causes Obesity and Affects Brain Glucose Metabolism in Rats

Estadella, D. and Oyama, L.M. and Bueno, Allain and Habitante, C.A. and Souza, G.I. and Ribeiro, E.B. and Motoyama, C.S.M. and Oller do Nascimento, C.M. (2011) A Palatable Hyperlipidic Diet Causes Obesity and Affects Brain Glucose Metabolism in Rats. Lipids in Health and Disease, 10 (168). pp. 1-9. ISSN 1476-511X

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Abstract

Background We have previously shown that either the continuous intake of a palatable hyperlipidic diet (H) or the alternation of chow (C) and an H diet (CH regimen) induced obesity in rats. Here, we investigated whether the time of the start and duration of these feeding regimens are relevant and whether they affect brain glucose metabolism. Methods Male Wistar rats received C, H, or CH diets during various periods of their life spans: days 30-60, days 30-90, or days 60-90. Experiments were performed the 60th or the 90th day of life. Rats were killed by decapitation. The glucose, insulin, leptin plasma concentration, and lipid content of the carcasses were determined. The brain was sliced and incubated with or without insulin for the analysis of glucose uptake, oxidation, and the conversion of [1-14C]-glucose to lipids. Results The relative carcass lipid content increased in all of the H and CH groups, and the H30-60 and H30-90 groups had the highest levels. Groups H30-60, H30-90, CH30-60, and CH30-90 exhibited a higher serum glucose level. Serum leptin increased in all H groups and in the CH60-90 and CH30-90 groups. Serum insulin was elevated in the H30-60, H60-90, CH60-90, CH30-90 groups. Basal brain glucose consumption and hypothalamic insulin receptor density were lower only in the CH30-60 group. The rate of brain lipogenesis was increased in the H30-90 and CH30-90 groups. Conclusion These findings indicate that both H and CH diet regimens increased body adiposity independent treatment and the age at which treatment was started, whereas these diets caused hyperglycemia and affected brain metabolism when started at an early age.

Item Type: Article
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Uncontrolled Keywords: palatable hyperlipidic diet, obesity, brain glucose metabolism, lipids, biochemistry, physiology, disease management
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Academic Departments > Institute of Science and the Environment
Related URLs:
Copyright Info: Open Access journal
Depositing User: Tanya Buchanan
Date Deposited: 09 Aug 2016 10:49
Last Modified: 09 Aug 2016 10:49
URI: https://eprints.worc.ac.uk/id/eprint/4754

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