University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Effectiveness of Nonpharmacologic Treatments for Acute Seasonal Allergic Conjunctivitis

Bilkhu, P.S. and Wolffsohn, J.S. and Naroo, S.A. and Robertson, Louise and Kennedy, Roy (2014) Effectiveness of Nonpharmacologic Treatments for Acute Seasonal Allergic Conjunctivitis. Ophthalmology, 121 (1). pp. 72-78. ISSN 0161-6420

Full text not available from this repository. (Request a copy)

Abstract

Objective To investigate whether artificial tears and cold compress alone or in combination provide a treatment benefit and whether they were as effective as or could enhance topical antiallergic medication. Design Randomized, masked clinical trial. Participants Eighteen subjects (mean age, 29.5±11.0 years) allergic to grass pollen. Intervention Controlled exposure to grass pollen using an environmental chamber to stimulate an ocular allergic reaction followed by application of artificial tears (ATs), 5 minutes of cold compress (CC), ATs combined with CC, or no treatment applied at each separate visit in random order. A subset of 11 subjects also had epinastine hydrochloride (EH) applied alone and combined with CC in random order or instillation of a volume-matched saline control. Main Outcome Measures Bulbar conjunctival hyperemia, ocular surface temperature, and ocular symptoms repeated before and every 10 minutes after treatment for 1 hour. Results Bulbar conjunctival hyperemia and ocular symptoms decreased and temperature recovered to baseline faster with nonpharmaceutical treatments compared with no treatment (P < 0.05). Artificial tears combined with CC reduced hyperemia more than other treatments (P < 0.05). The treatment effect of EH was enhanced by combining it with a CC (P < 0.001). Cold compress combined with ATs or EH lowered the antigen-raised ocular surface temperature to less than the pre-exposure baseline. Artificial tear instillation alone or CC combined with ATs or EH significantly reduced the temperature (P < 0.05). Cold compress combined with ATs or EH had a similar cooling effect (P > 0.05). At all measurement intervals, symptoms were reduced for both EH and EH combined with CC than CC or ATs alone or in combination (P < 0.014). Conclusions After controlled exposure to grass pollen, CC and AT treatment showed a therapeutic effect on the signs and symptoms of allergic conjunctivitis. A CC enhanced the use of EH alone and was the only treatment to reduce symptoms to baseline within 1 hour of antigenic challenge. Signs of allergic conjunctivitis generally were reduced most by a combination of a CC in combination with ATs or EH.

Item Type: Article
Additional Information:

The full-text cannot be supplied for this item. Please check availability with your local library or Interlibrary Requests Service.

Originally deposited as National Pollen and Aerobiology Research Unit (NPARU)

Uncontrolled Keywords: nonpharmacologic treatments, acute seasonal allergic conjunctivitis
Subjects: R Medicine > RE Ophthalmology
Divisions: Academic Departments > Institute of Science and the Environment
Related URLs:
Depositing User: Sally Wall
Date Deposited: 30 Sep 2013 15:11
Last Modified: 18 Feb 2016 12:40
URI: https://eprints.worc.ac.uk/id/eprint/2413

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.