Chan, Y., Zuo, J., Inman, C., Croft, W., Begum, J., Croudace, Joanne, Kinsella, F., Maggs, L., Nagra, S., Nunnick, J., Abbotts, B., Craddock, C., Malladi, R. and Moss, P. (2017) NK cells produce high levels of IL-10 early after allogeneic stem cell transplantation and suppress development of acute GVHD. European Journal of Immunology, 48 (2). pp. 316-329. ISSN Print: 0014-2980 Electronic: 1521-4141
|
Text
Eur J Immunol - 2017 - Chan - NK cells produce high levels of IL‐10 early after allogeneic stem cell transplantation and.pdf - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue. Spontaneous production of the immunoregulatory cytokine IL-10 was observed in over 70% of cells and transcription of cytokines and growth factors was augmented. NK-14 cell number was inversely correlated with the incidence of grade II-IV acute graft versus host disease (GVHD). These findings reveal that robust reconstitution of immunoregulatory NK cells by day 14 after allo-SCT is an important determinant of the clinical outcome, suggesting that NK cells may suppress the development of the T cell-mediated alloreactive immune response through production of IL-10.
Item Type: | Article |
---|---|
Uncontrolled Discrete Keywords: | Allo-SCT, T cells depleted, NK cells, IL-10, GVHD |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
Related URLs: | |
Copyright Info: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited., © 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Depositing User: | Joanne Whittaker |
Date Deposited: | 13 Mar 2024 10:51 |
Last Modified: | 20 Mar 2024 13:15 |
URI: | https://eprints.worc.ac.uk/id/eprint/13710 |
Actions (login required)
![]() |
View Item |