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Timing of Plant Immune Responses by a Central Circadian Regulator

Wang, Wei and Barnaby, Jinyoung Yang and Tada, Yasuomi and Li, Haira and Tör, M and Caldelari, Daniela and Lee, Dae-un and Fu, Xiang-Dong and Dong, Xinnian (2011) Timing of Plant Immune Responses by a Central Circadian Regulator. Nature, 410. pp. 110-114. ISSN Print: 0028-0836 Online: 1476-4687

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Abstract

The principal immune mechanism against biotrophic pathogens in plants is the resistance (R)-gene-mediated defence1. It was proposed to share components with the broad-spectrum basal defence machinery2. However, the underlying molecular mechanism is largely unknown. Here we report the identification of novel genes involved in R-gene-mediated resistance against downy mildew in Arabidopsis and their regulatory control by the circadian regulator, CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1). Numerical clustering based on phenotypes of these gene mutants revealed that programmed cell death (PCD) is the major contributor to resistance. Mutants compromised in the R-gene-mediated PCD were also defective in basal resistance, establishing an interconnection between these two distinct defence mechanisms. Surprisingly, we found that these new defence genes are under circadian control by CCA1, allowing plants to ‘anticipate’ infection at dawn when the pathogen normally disperses the spores and time immune responses according to the perception of different pathogenic signals upon infection. Temporal control of the defence genes by CCA1 differentiates their involvement in basal and R-gene-mediated defence. Our study has revealed a key functional link between the circadian clock and plant immunity

Item Type: Article
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Uncontrolled Keywords: immune mechanisms, biotrophic pathogens, plant immunity, downy mildew, Arabidopsis, circadian regulator
Subjects: Q Science > QK Botany
Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR180 Immunology
Divisions: Academic Departments > Institute of Science and the Environment
Research Centres > National Pollen and Aerobiology Research Unit
Depositing User: Janet Davidson
Date Deposited: 08 Feb 2011 11:42
Last Modified: 08 Feb 2011 11:42
URI: https://eprints.worc.ac.uk/id/eprint/1268

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