University of Worcester Worcester Research and Publications

Small RNA-based plant protection against diseases

Bilir, Ö., Göl, Deniz, Hong, Yiguo, McDowell, J. M. and Tör, M. ORCID: (2022) Small RNA-based plant protection against diseases. Frontiers in Plant Science, 13 (951097). ISSN 1664-462X

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Plant diseases cause significant decreases in yield and quality of crops and consequently pose a very substantial threat to food security. In the continuous search for environmentally friendly crop protection, exploitation of RNA interferance machinery is showing promising results. It is well established that small RNAs (sRNAs) including microRNA (miRNA) and small interfering RNA (siRNA) are involved in the regulation of gene expression via both transcriptional and post-transcriptional RNA silencing. sRNAs from host plants can enter into pathogen cells during invasion and silence pathogen genes. This process has been exploited through Host-Induced Gene Silencing (HIGS), in which plant transgenes that produce sRNAs are engineered to silence pest and pathogen genes. Similarly, exogenously applied sRNAs can enter pest and pathogen cells, either directly or via the hosts, and silence target genes. This process has been exploited in Spray-Induced Gene Silencing (SIGS). Here, we focus on the role of sRNAs and review how they have recently been used against various plant pathogens through HIGS or SIGS-based methods and discuss advantages and drawbacks of these approaches.

Item Type: Article
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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Uncontrolled Discrete Keywords: HIGS, SIGS, sRNA, plant protection, pathogens, SERG
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Copyright Info: © 2022 Bilir, Göl, Hong, McDowell and Tör.
Depositing User: Miranda Jones
Date Deposited: 18 Aug 2022 14:56
Last Modified: 20 Oct 2022 14:56

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