University of Worcester Worcester Research and Publications

Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy mildew Resistance Genes

Tör, M. and Gordon, P. and Cuzick, A. and Eulgem, T. and Sinapidou, E. and Mert-Türk, F. and Can, C. and Dangl, J.L. (2002) Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy mildew Resistance Genes. Plant Cell, 14 (5). pp. 993-1003. ISSN Print: 1040-4651 Online: 1532-298X

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We describe the identification of a mutant in the Arabidopsis accession Columbia (Col-0) that exhibits enhanced downy mildew (edm1) susceptibility to several Peronospora parasitica isolates, including the RPP7-diagnostic isolate Hiks1. The mutation was mapped to chromosome IV and characterized physically as a 35-kb deletion spanning seven genes. One of these genes complemented the mutant to full wild-type resistance against all of the Peronospora isolates tested. This gene (AtSGT1b) encodes a predicted protein of 39.8 kD and is an Arabidopsis ortholog of yeast SGT1, which was described originally as a key regulatory protein in centromere function and ubiquitin-mediated proteolysis. AtSGT1b contains three tetratricopeptide repeats at the N terminus followed by a bipartite chord-containing SGT domain and an SGT-specific domain at the C terminus. We discuss the role of AtSGT1b in disease resistance and its possible involvement in ubiquitin-mediated proteolysis in plants.

Item Type: Article
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This is an Open Access article. The full-text can be accessed via the Official URL.

Uncontrolled Keywords: Arabidopsis, defence signaling, downy mildew genes
Subjects: Q Science > QK Botany
Q Science > QH Natural history > QH426 Genetics
Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology
Divisions: Academic Departments > Institute of Science and the Environment
Research Centres > National Pollen and Aerobiology Research Unit
Depositing User: Janet Davidson
Date Deposited: 19 Jan 2011 19:53
Last Modified: 26 Jul 2015 08:40

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