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A Naturally Occurring Epigenetic Mutation in a Gene Encoding an SBP-box Transcription Factor Inhibits Tomato Fruit Ripening

Manning, K. and Tör, M. and Walley, P. and Poole, M. and Puddephat, I. and Thompson, A.J. and King, G.J. and Giovannoni, J.J. and Seymour, G. (2006) A Naturally Occurring Epigenetic Mutation in a Gene Encoding an SBP-box Transcription Factor Inhibits Tomato Fruit Ripening. Nature Genetics, 38 (8). pp. 948-952.

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Abstract

A major component in the regulatory network controlling fruit ripening is likely to be the gene at the tomato Colorless non-ripening (Cnr) locus1, 2. The Cnr mutation results in colorless fruits with a substantial loss of cell-to-cell adhesion. The nature of the mutation and the identity of the Cnr gene were previously unknown. Using positional cloning and virus-induced gene silencing, here we demonstrate that an SBP-box (SQUAMOSA promoter binding protein–like) gene resides at the Cnr locus. Furthermore, the Cnr phenotype results from a spontaneous epigenetic change in the SBP-box promoter. The discovery that Cnr is an epimutation was unexpected, as very few spontaneous epimutations have been described in plants3, 4. This study demonstrates that an SBP-box gene is critical for normal ripening and highlights the likely importance of epialleles in plant development and the generation of natural variation.

Item Type: Article
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Uncontrolled Keywords: epigenetic mutation, gene encoding, gene expression, genetics, epigenetics, tomato fruit
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
Divisions: Academic Departments > Institute of Science and the Environment
Research Centres > National Pollen and Aerobiology Research Unit
Depositing User: Janet Davidson
Date Deposited: 19 Jan 2011 19:45
Last Modified: 26 Jul 2015 08:33
URI: https://eprints.worc.ac.uk/id/eprint/1166

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