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The Greatful Dead: Damage-Associated Molecular Pattern Molecules and Reduction/Oxidation Regulate Immunity.

Lotze, M.T. and Zeh, H.J. and Rubartelli, A. and Sparvero, L.J. and Amoscata, A.A. and Washburn, N.R. and Devera, M.E. and Liang, X. and Tör, M and Billiar, T. (2007) The Greatful Dead: Damage-Associated Molecular Pattern Molecules and Reduction/Oxidation Regulate Immunity. Immunological Reviews, 220 (1). pp. 60-81. ISSN 1600-065X

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Abstract

The response to pathogens and damage in plants and animals involves a series of carefully orchestrated, highly evolved, molecular mechanisms resulting in pathogen resistance and wound healing. In metazoans, damage- or pathogen-associated molecular pattern molecules (DAMPs, PAMPs) execute precise intracellular tasks and are also able to exert disparate functions when released into the extracellular space. The emergent consequence for both inflammation and wound healing of the abnormal extracellular persistence of these factors may underlie many clinical disorders. DAMPs/PAMPs are recognized by hereditable receptors including the Toll-like receptors, the NOD1-like receptors and retinoic-acid-inducible gene I-like receptors, as well as the receptor for advanced glycation end products. These host molecules ‘sense’ not only pathogens but also misfolded/glycated proteins or exposed hydrophobic portions of molecules, activating intracellular cascades that lead to an inflammatory response. Equally important are means to not only respond to these molecules but also to eradicate them. We have speculated that their destruction through oxidative mechanisms normally exerted by myeloid cells, such as neutrophils and eosinophils, or their persistence in the setting of pathologic extracellular reducing environments, maintained by exuberant necrotic cell death and/or oxidoreductases, represent important molecular means enabling chronic inflammatory states.

Item Type: Article
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Uncontrolled Keywords: DAMPS, PAMPS, redox, HMGB1, TLR4, RAGE, immunology, molecular immunology
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
Divisions: Academic Departments > Institute of Science and the Environment
Research Centres > National Pollen and Aerobiology Research Unit
Depositing User: Janet Davidson
Date Deposited: 19 Jan 2011 19:40
Last Modified: 27 Nov 2014 08:46
URI: https://eprints.worc.ac.uk/id/eprint/1163

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