Chataigner, M., Lucas, C., Di Miceli, Mathieu ORCID: https://orcid.org/0000-0003-3713-0370, Pallet, V., Laye, S., Mahaignerie, A., Bouvret, E., Dinnel, A.L. and Joffre, C.
(2021)
Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging.
Frontiers in Nutrition, 8 (75029).
ISSN 2296-861X
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Chataigner Joffre Dinel et al 2021 Front Nutr.pdf - Published Version Available under License Creative Commons Attribution. Download (3MB) | Preview |
Abstract
Brain aging is characterized by a chronic low-grade inflammation, which significantly impairs cognitive function. Microglial cells, the immunocompetent cells of the brain, present a different phenotype, switching from a homeostatic signature (M0) to a more reactive phenotype called “MGnD” (microglial neurodegenerative phenotype), leading to a high production of pro-inflammatory cytokines. Furthermore, microglial cells can be activated by age-induced gut dysbiosis through the vagus nerve or the modulation of the peripheral immune system. Nutrients, in particular n-3 long chain polyunsaturated fatty acids (LC-PUFAs) and low molecular weight peptides, display powerful immunomodulatory properties, and can thus prevent age-related cognitive decline. The objective of this study was to investigate the effects of n-3 LC-PUFAs and low molecular weight peptides contained in a marine by-product-derived hydrolysate on microglial phenotypes and intestinal permeability and their consequences on cognition in mice. We demonstrated that the hydrolysate supplementation for 8 weeks prevented short- and long-term memory decline during aging. These observations were linked to the modulation of microglial signature. Indeed, the hydrolysate supplementation promoted homeostatic microglial phenotype by increasing TGF-β1 expression and stimulated phagocytosis by increasing Clec7a expression. Moreover, the hydrolysate supplementation promoted anti-inflammatory intestinal pathway and tended to prevent intestinal permeability alteration occurring during aging. Therefore, the fish hydrolysate appears as an interesting candidate to prevent cognitive decline during aging.
Item Type: | Article |
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Uncontrolled Discrete Keywords: | n-3 long chain PUFA, low molecular weight peptides, microglia, memory, hydrolysate, cognitive decline, aging |
Subjects: | Q Science > QH Natural history > QH301 Biology |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
Related URLs: | |
Copyright Info: | Open Access, © 2021 Chataigner, Lucas, Di Miceli, Pallet, Laye, Mehaignerie, Bouvret, Dinel and Joffre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forum |
Depositing User: | Mathieu Di Miceli |
Date Deposited: | 26 Nov 2021 18:31 |
Last Modified: | 26 Nov 2021 18:31 |
URI: | https://eprints.worc.ac.uk/id/eprint/11524 |
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