Mason, Victoria L and Wiles, N and Hollinghurst, Sandra and Musa, Meyrem and Burt, Victoria and Hyde, Julia and Jerrom, Bill and Lewis, Glyn and Kessler, David (2008) A Randomised Controlled Trial of Cognitive Behavioural Therapy as an Adjunct to Pharmacotherapy in Primary Care Based Patients with Treatment Resistant Depression: a Pilot Study (ISRCTN81845520). Behavioural and Cognitive Psychotherapy, 36 (1). pp. 21-33. ISSN 1352-4658
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No randomised controlled trials (RCTs) have been conducted of cognitive behavioural therapy (CBT) for depressed patients who have not responded to antidepressants, yet CBT is often reserved for this group. We conducted a pilot study for a pragmatic RCT of the clinical effectiveness of CBT as an adjunct to pharmacotherapy in primary care based patients with treatment resistant depression (TRD). Patients on antidepressants for at least 6 weeks were mailed a study invitation by their GP. Those who consented to contact were mailed a questionnaire. TRD was defined as compliance with medication (self-report) and Beck Depression Inventory (BDI) ≥ 15. Those who met ICD-10 depression criteria were eligible for randomisation and followed after 4 months. Of 440 patients mailed, 65% responded and 72% consented to contact. 94% completed the questionnaire and 82 patients (42%) had TRD. Thirty were subsequently identified as ineligible and 10 did not participate further. Twenty-six of the remaining 42 patients met ICD-10 depression criteria and 25 agreed to being randomised. 23 patients completed the 4-month follow-up questionnaire. Recruitment into a RCT to examine the effectiveness of CBT as an adjunct to pharmacotherapy in primary care based patients with TRD appears feasible and should now be conducted.
|Uncontrolled Keywords:||treatment resistance, depression, primary care, cognitive behavioural therapy, CBT, randomised controlled trials, pharmacotherapy|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry|
B Philosophy. Psychology. Religion > BF Psychology
|Divisions:||Academic Departments > Institute of Health and Society|
|Deposited By:||Victoria Mason|
|Deposited On:||31 Jan 2008 10:00|
|Last Modified:||24 May 2013 06:00|
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