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Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Coleman, J., Peyrot, W.J., Purves, K.L., Davis, K., Rayner, C., Choi, S.W., Hubel, C., Gaspar, H., Kan, C., Vander der Auwera, S., Adams, M., Lyall, D., Choi, K., Major Depressive Working Group of the PGC, , Dunn, E., Vassos, E., Danese, A., Maughan, B., Grabe, H., Lewis, C., O'Reilly, P.F., McIntosh, A., Smith, D., Wray, N., Hotopf, M., Eley, T., Breen, G. and Jones, Lisa (2019) Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry. ISSN Print: 1359-4184 Online: 1476-5578 (In Press)

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Abstract

Depression is more frequent among individuals exposed to traumatic events.Both trauma exposure and depression are heritable. However, the relationship
between these traits, including the role of genetic risk factors, is complex and poorly understood. When modelling trauma exposure as an environmental influence on
depression, both gene-environment correlations and gene-environment interactions have been observed. The UK Biobank concurrently assessed Major Depressive Disorder (MDD) and self-reported lifetime exposure to traumatic events in 126,522 genotyped individuals of European ancestry. We contrasted genetic influences on MDD between individuals reporting and not reporting trauma exposure (final sample
size range: 24,094-92,957). The SNP-based heritability of MDD was greater in participants reporting trauma exposure (24%) than in individuals not reporting trauma exposure taking into account the strong, positive genetic correlation observed between MDD and reported trauma exposure. The genetic correlation between MDD
15 and waist circumference was only significant in individuals reporting trauma exposure (rg = 0.24, p = 1.8x10-7 versus rg = -0.05, p = 0.39 in individuals not
reporting trauma exposure, difference p = 2.3x10-4). Our results suggest that the genetic contribution to MDD is greater when additional risk factors are present, and
that a complex relationship exists between reported trauma exposure, body composition, and MDD.

Item Type: Article
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Uncontrolled Keywords: genome-wide, gene environment, major depressive disorder, traumatic experiences, UK Biobank
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
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Depositing User: Katherine Gordon-Smith
Date Deposited: 26 Nov 2019 16:09
Last Modified: 28 Nov 2019 08:59
URI: https://eprints.worc.ac.uk/id/eprint/8915

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