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Amino Acid-modified Spray-dried Powders with Enhanced Aerosolisation Properties for Pulmonary Drug Delivery

Seville, Peter C. ORCID: https://orcid.org/0000-0001-8546-3474, Learoyd, T.P., Li, H.-Y., Williamson, I.J. and Birchall, J.C. (2007) Amino Acid-modified Spray-dried Powders with Enhanced Aerosolisation Properties for Pulmonary Drug Delivery. Powder Technology, 178 (1). pp. 40-50. ISSN Print: 0032-5910 Online: 1873-328X

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Abstract

In this study, the amino acids arginine, aspartic acid, leucine, phenylalanine and threonine were investigated as ‘dispersibility enhancers’ in spray-dried powders for inhalation. Parameters such as spray-dried yield, tapped density, and Carr's Index were not predictive of aerosolisation performance. In addition, whilst the majority of amino acid-modified powders displayed suitable particle size distribution for pulmonary administration and potentially favourable low moisture content, in vitro particle deposition was only enhanced for the leucine-modified powder. In summary, leucine can be used to enhance the dispersibility and aerosolisation properties of spray-dried powders for pulmonary drug delivery.

Item Type: Article
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Uncontrolled Keywords: spray-drying, salbutamol sulphate, amino acids, dispersibility, pulmonary deposition
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Peter Seville
Date Deposited: 17 Jun 2019 10:43
Last Modified: 17 Jun 2019 10:43
URI: https://eprints.worc.ac.uk/id/eprint/8190

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