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Sustained Delivery of Salbutamol and Beclometasone From Spray-dried Double Emulsions

Learoyd, T.P., Burrows, J.L., French, E. and Seville, Peter C. ORCID: https://orcid.org/0000-0001-8546-3474 (2010) Sustained Delivery of Salbutamol and Beclometasone From Spray-dried Double Emulsions. Journal of Microencapsulation, 27 (2). pp. 162-170. ISSN Print: 0265-2048 Online: 1464-5246

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Abstract

The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or beclometasone dipropionate in varying phases. The double emulsions contained the drug release modifier polylactide co-glycolide (PLGA 50 : 50) in the intermediate organic phase of the original micro-emulsion and low molecular weight chitosan (Mw<190 kDa: emulsion stabilizer) and leucine (aerosolization enhancer) in the tertiary aqueous phase. Following spray-drying resultant powders were physically characterized: with in vitro aerosolization performance and drug release investigated using a Multi-Stage Liquid Impinger and modified USP II dissolution apparatus, respectively. Powders generated were of a respirable size exhibiting emitted doses of over 95% and fine particle fractions of up to 60% of the total loaded dose. Sustained drug release profiles were observed during dissolution for powders containing agents in the primary aqueous and secondary organic phases of the original micro-emulsion; the burst release of agents was witnessed from the tertiary aqueous phase. The novel spray-dried emulsions from this study would be expected to deposit and display sustained release character in the lung.

Item Type: Article
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Uncontrolled Keywords: spray drying, chitosan, double emulsion, PLGA, respirable
Subjects: Q Science > Q Science (General)
Q Science > QC Physics
Q Science > QD Chemistry
Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Academic Departments > Institute of Science and the Environment
Related URLs:
Depositing User: Peter Seville
Date Deposited: 17 Jun 2019 11:08
Last Modified: 17 Jun 2019 11:08
URI: https://eprints.worc.ac.uk/id/eprint/8184

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