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Influence of Excipients on Spray-dried Powders for Inhalation

Xu, E-Y., Guo, J., Xu, Y., Li, H.-Y. and Seville, Peter C. ORCID: https://orcid.org/0000-0001-8546-3474 (2014) Influence of Excipients on Spray-dried Powders for Inhalation. Powder Technology, 256. 217 - 223. ISSN Print : 0032-5910 Online: 1873-328X

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Abstract

Two areas attracting considerable attention when developing effective pulmonary drug delivery systems include the improvement of aerosolisation efficiency of the inhaled formulation and the controlled release of drug from the formulation following deposition within the lung. In this study, four saccharides were employed as excipients in the preparation of spray-dried powder formulations for the pulmonary drug delivery. Beta-cyclodextrin-, starch-, and sodium carboxymethylcellulose (NaCMC)-based spray-dried powders showed a significant (one-way ANOVA, Duncan's test, p<0.05) increase in lower stage drug deposition in the Next Generation Impactor (NGI) when compared to lactose-based spray-dried powders. Furthermore, NaCMC-based spray-dried powder formulations exhibited a sustained drug release profile in dissolution testing; approximately 80 of salbutamol sulphate was released after an hour, whereas drug from the lactose-based spray-dried powder formulation was released within 5min. Our results clearly demonstrate that the inclusion of NaCMC in spray-dried powder formulations increases the aerosolisation efficiency of the powder and also offers the potential for sustained drug release, which may be of benefit in the treatment of local and systemic conditions.

Item Type: Article
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The full-text of accepted version can be accessed via http://clok.uclan.ac.uk/13610/

Uncontrolled Keywords: saccharides, pulmonary delivery, sustained release, aerosolisation
Divisions: Divisions (2019 and before) > Academic Departments > Institute of Science and the Environment
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Depositing User: Peter Seville
Date Deposited: 18 Feb 2019 12:01
Last Modified: 21 Nov 2019 09:09
URI: https://eprints.worc.ac.uk/id/eprint/7557

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