University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Stratification of the Risk of Bipolar Disorder Recurrences in Pregnancy and Postpartum

Di Florio, A., Gordon-Smith, Katherine, Forty, L., Kosorok, M.R., Fraser, C., Perry, Amy, Bethell, A., Craddock, N., Jones, Lisa and Jones, Ian (2018) Stratification of the Risk of Bipolar Disorder Recurrences in Pregnancy and Postpartum. The British Journal of Psychiatry, 213 (3). pp. 542-547. ISSN Print: 0007-1250 Online: 1472-1465

[img]
Preview
Text
div-class-title-stratification-of-the-risk-of-bipolar-disorder-recurrences-in-pregnancy-and-postpartum-div.pdf

Download (332kB) | Preview

Abstract

Background Pregnancy and childbirth are a period of high risk for women with bipolar disorder and involve difficult decisions particularly about continuing or stopping medications. Aims To explore what clinical predictors may help to individualise the risk of perinatal recurrence in women with bipolar disorder. Method Information was gathered retrospectively by semi-structured interview, questionnaires and case-note review from 887 women with bipolar disorder who have had children. Clinical predictors were selected using backwards stepwise logistic regression, conditional permutation random forests and reinforcement learning trees. Results Previous perinatal history of affective psychosis or depression was the most significant predictor of a perinatal recurrence (odds ratio (OR) = 8.5, 95% CI 5.04–14.82 and OR = 3.6, 95% CI 2.55–5.07 respectively) but even parous women with bipolar disorder without a previous perinatal mood episode were at risk following a subsequent pregnancy, with 7% developing postpartum psychosis. Conclusions Previous perinatal history of affective psychosis or depression is the most important predictor of perinatal recurrence in women with bipolar

Item Type: Article
Additional Information:

The full-text of the published version can be accessed via the official URL.

Uncontrolled Keywords: bipolar disorder, pregnancy, childbirth, postpartum, perinatal recurrence, depression, psychosis
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
Related URLs:
Copyright Info: Open Access article
Depositing User: Katherine Gordon-Smith
Date Deposited: 05 Jul 2018 09:53
Last Modified: 02 Jan 2019 11:12
URI: https://eprints.worc.ac.uk/id/eprint/6751

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.