Swaden Lewis, K., Gordon-Smith, Katherine ORCID: https://orcid.org/0000-0003-4083-1143, Forty, L., Di Florio, A., Craddock, N., Jones, Lisa ORCID: https://orcid.org/0000-0002-5122-8334 and Jones, I. (2017) Sleep Loss as a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender. British Journal of Psychiatry, 211 (3). pp. 169-174. ISSN 0007-1250 Online:1472-1465
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Abstract
Background: Sleep loss may trigger mood episodes in people with bipolar disorder (BD) but individual differences could influence vulnerability to this trigger.
Aims: To determine whether bipolar subtype (BD-I or BD-II) and gender were associated with vulnerability to the sleep loss trigger.
Method: During a semi-structured interview, 3140 individuals (68% female) with BD (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case note and interview data.
Results: Sleep loss triggering episodes of high mood was associated with female gender (OR = 1.43, 95% CI 1.17-1.75, P <.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, P <.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders.
Conclusions: Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift-work and international travel.
Item Type: | Article |
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Additional Information: | The full-text can be accessed via the Official URL. |
Uncontrolled Discrete Keywords: | sleep loss, bipolar disorder, diagnostic subtype, gender |
Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Divisions: | College of Health, Life and Environmental Sciences > School of Allied Health and Community |
Related URLs: | |
Depositing User: | Katherine Gordon-Smith |
Date Deposited: | 19 May 2017 07:23 |
Last Modified: | 09 Jul 2020 11:06 |
URI: | https://eprints.worc.ac.uk/id/eprint/5515 |
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