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Sleep Loss as a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender

Swaden Lewis, K. and Gordon-Smith, Katherine and Forty, L. and Di Florio, A. and Craddock, N. and Jones, Lisa and Jones, I. (2017) Sleep Loss as a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender. British Journal of Psychiatry, 211 (3). pp. 169-174. ISSN 0007-1250 Online:1472-1465

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Abstract

Background: Sleep loss may trigger mood episodes in people with bipolar disorder (BD) but individual differences could influence vulnerability to this trigger. Aims: To determine whether bipolar subtype (BD-I or BD-II) and gender were associated with vulnerability to the sleep loss trigger. Method: During a semi-structured interview, 3140 individuals (68% female) with BD (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case note and interview data. Results: Sleep loss triggering episodes of high mood was associated with female gender (OR = 1.43, 95% CI 1.17-1.75, P <.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, P <.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders. Conclusions: Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift-work and international travel.

Item Type: Article
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The full-text can be accessed via the Official URL.

Uncontrolled Keywords: sleep loss, bipolar disorder, diagnostic subtype, gender
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Katherine Gordon-Smith
Date Deposited: 19 May 2017 07:23
Last Modified: 07 Nov 2017 11:19
URI: https://eprints.worc.ac.uk/id/eprint/5515

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