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EDM2 is Required For RPP7-Dependent Disease Resistance in Arabidopsis and Affects RPP7 Transcript Levels

Eulgem, T. and Tsuchiya, T. and Wang, X. and Beasley, B. and Cuzick, A. and Tör, M and Zhu, T. and McDowell, J.M. and Holub, E. and Dangl, J.L. (2007) EDM2 is Required For RPP7-Dependent Disease Resistance in Arabidopsis and Affects RPP7 Transcript Levels. The Plant Journal, 49 (5). pp. 829-839. ISSN Print: 0960-7412 Online: 1365-313X

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Abstract

Specific disease resistance of Arabidopsis thaliana against the Hyaloperonospora parasitica isolate Hiks1 (HpHiks1) is mediated by RPP7. Although this disease resistance gene encodes a typical nucleotide binding site leucine-rich repeat (NB-LRR) disease resistance protein, its function is independent of the defense hormone salicylic acid and most known genes required for plant immune responses. We identified EDM2 (enhanced downy mildew 2) in a genetic screen for RPP7 suppressors. Mutations of EDM2 phenocopy RPP7 mutations, but do not affect other tested disease resistance genes. We isolated EDM2 by map-based cloning. The predicted EDM2 protein is structurally unrelated to previously identified components of the plant immune system, bears typical features of transcriptional regulators, including plant homeodomain (PHD)-finger-like domains, and defines a plant-specific protein family. In edm2 mutants both constitutive and HpHiks1-induced RPP7 transcript levels are reduced, suggesting that EDM2 is either a direct or an indirect regulator of RPP7 expression. Microarray analyses defined a set of defense-associated genes, the expression of which is suppressed during successful HpHiks1 colonization of either rpp7 or edm2 plants. This transcriptional phenotype is counteracted by an EDM2/RPP7-dependent mechanism

Item Type: Article
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This is an Open Access article. The full-text can be accessed via the Official URL.

Uncontrolled Keywords: Arabidopsis thaliana, Hyaloperonospora parasitica, disease resistance gene, EDM2 (enhanced downy mildew 2)-like proteins (ELPs), plant homeodomain (PHD) finger, Arabidopsis
Subjects: Q Science > QK Botany
Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology
Divisions: Academic Departments > Institute of Science and the Environment
Research Centres > National Pollen and Aerobiology Research Unit
Depositing User: Janet Davidson
Date Deposited: 19 Jan 2011 19:42
Last Modified: 05 Dec 2014 17:02
URI: https://eprints.worc.ac.uk/id/eprint/1164

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