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Melhuish Beaupre, L.M., Tiwari, A.K., Gonçalves, V.F., Zai, C.C., Marshe, V.S., Lewis, C.M., Martin, N.G., McIntosh, A.M., Adams, M.J., Baune, B.T., Levinson, D.F., Boomsma, D.I., Penninx, B.W.J.H., Breen, G., Hamilton, S., Awasthi, S., Ripke, S., Jones, Lisa 
ORCID: https://orcid.org/0000-0002-5122-8334, Jones, I., Byrne, E.M., Hickie, I.B., Potash, J.P., Shi, J., Weissman, M.M., Milaneschi, Y., Shyn, S.I., de Geus, E.J.C, Willemsen, G., Brown, G.M., Kennedy, J.L. and Major Depressive Disorder Working Group,
(2021)
Potential Genetic Overlap Between
Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis.
Frontiers in Psychiatry, 12.
p. 2118.
ISSN Online: 1664-0640
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Text (Open Access article)
fpsyt-12-734077.pdf - Published Version Available under License Creative Commons Attribution. Download (313kB) | Preview |
Abstract
Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidated, a recent genome-wide association (GWAS) of insomnia, and other sleep traits in over 1 million individuals was recently published and provides many promising hits for genetics of insomnia in a population-based sample.
Methods: Using data from the largest available GWAS of insomnia and other sleep traits, we sought to test if sleep variable PRS scores derived from population-based studies predicted sleep variables in samples of depressed cases [Psychiatric Genomics Consortium - Major Depressive Disorder subjects (PGC MDD)]. A leave-one-out analysis was performed to determine the effects that each individual study had on our results.
Results: The only significant finding was for insomnia, where p-value threshold, p = 0.05 was associated with insomnia in our PGC MDD sample (R2 = 1.75−3, p = 0.006).
Conclusion: Our results reveal that <1% of variance is explained by the variants that cover the two significant p-value thresholds, which is in line with the fact that depression and insomnia are both polygenic disorders. To the best of our knowledge, this is the first study to investigate genetic overlap between the general population and a depression sample for insomnia, which has important treatment implications, such as leading to novel drug targets in future research efforts.
| Item Type: | Article |
|---|---|
| Additional Information: | Copyright © 2021 Melhuish Beaupre, Tiwari, Gonçalves, Zai, Marshe, Lewis, Martin, Funding: This project was supported by the Frederick Banting and Charles |
| Uncontrolled Discrete Keywords: | sleep, major depressive disorder, insomnia,, hypersomnia,, polygenic risk |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | College of Health, Life and Environmental Sciences > School of Allied Health and Community |
| Related URLs: | |
| Depositing User: | Katherine Gordon-Smith |
| Date Deposited: | 22 Dec 2021 17:53 |
| Last Modified: | 22 Dec 2021 17:53 |
| URI: | https://eprints.worc.ac.uk/id/eprint/11582 |
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