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Diagnostic Yield of Transbronchial Lung Cryobiopsy Compared to Transbronchial Forceps Biopsy in Patients with Sarcoidosis in a Prospective, Randomized, Multicentre Cross-Over Trial

Häntschel, M., Eberhardt, R., Petermann, C., Gesierich, W., Darwiche, K., Hagmeyer, L., Colby, T.V., Fend, F., Theegarten, D., Wintzer, H., Kreuter, M., Spengler, W., Behrens-Zemek, A.F., Lewis, Richard A., Evrard, H.C., Ehab, A., Böckeler, M. and Hetzel, J. (2021) Diagnostic Yield of Transbronchial Lung Cryobiopsy Compared to Transbronchial Forceps Biopsy in Patients with Sarcoidosis in a Prospective, Randomized, Multicentre Cross-Over Trial. Journal of Clinical Medicine, 10 (23). p. 5686. ISSN EISSN 2077-0383

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Abstract

Background: Transbronchial lung forceps biopsy (TBLF) is of limited value for the diagnosis of interstitial lung disease (ILD). However, in cases with predominantly peribronchial pathology, such as sarcoidosis, TBLF is considered to be diagnostic in most cases. The present study examines whether transbronchial lung cryobiopsy (TBLC) is superior to TBLF in terms of diagnostic yield in cases of sarcoidosis. Methods: In this post hoc analysis of a prospective, randomized, controlled, multicentre study, 359 patients with ILD requiring diagnostic bronchoscopic tissue sampling were included. TBLF and TBLC were both used for each patient in a randomized order. Histological assessment was undertaken on each biopsy and determined whether sarcoid was a consideration. Results: A histological diagnosis of sarcoidosis was established in 17 of 272 cases for which histopathology was available. In 6 out of 17 patients, compatible findings were seen with both TBLC and TBLF. In 10 patients, where the diagnosis of sarcoidosis was confirmed by TBLC, TBLF did not provide a diagnosis. In one patient, TBLF but not TBLC confirmed the diagnosis of sarcoidosis. Conclusions: In this post hoc analysis, the histological diagnosis of sarcoidosis was made significantly more often by TBLC than by TBLF. As in other idiopathic interstitial pneumonias (IIPs), the use of TBLC should be considered when sarcoidosis is suspected.

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Copyright: © 2021 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).

Uncontrolled Discrete Keywords: sarcoidosis, bronchoscopy, transbronchial biopsy, cryobiopsy
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Miranda Jones
Date Deposited: 21 Dec 2021 09:49
Last Modified: 21 Dec 2021 09:49
URI: https://eprints.worc.ac.uk/id/eprint/11570

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